tyrosine hydroxylase

Pathways Recommended:	Protein Tyrosine Kinase/RTK

By Targets:	5-HT Receptor (1) Biochemical Assay Reagents (2) COX (2) Cyclic GMP-AMP Synthase (1) Dopamine Receptor (2) Endogenous Metabolite (2) ERK (1) Fungal (1) Isotope-Labeled Compounds (1) NF-κB (1) Nuclear Hormone Receptor 4A/NR4A (1) Parasite (1) PKA (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (4)

Targets Recommended: Tryptophan Hydroxylase Dopamine β-hydroxylase HIF/HIF Prolyl-Hydroxylase Btk Syk DYRK Pyk2 BRK FAK FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W008452

H-Tyr(3-I)-OH	Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH is a potent and effective **tyrosine hydroxylase** inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-123468

HA-1004	Cyclic GMP-AMP Synthase PKA ERK	Cardiovascular Disease Metabolic Disease
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HY-W677684

Nurr1 agonist 2	Nuclear Hormone Receptor 4A/NR4A	Others
Nurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC₅₀: 0.07 μM). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a K_d value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression .

HY-N3550

Catalponol	Others	Cancer
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-W071686

6-Methyltetrahydropterin dihydrochloride	Biochemical Assay Reagents	Others
6-Methyltetrahydropterin (dihydrochloride) is a biochemical detection reagent that can be used in **tyrosine hydroxylase** activity assay .

HY-33549

α-Methyl-p-tyrosine
α-Methyl-p-tyrosine is a competitive inhibitor of the enzyme **tyrosine hydroxylase*, which converts tyrosine* to Levodopa (DOPA). α-Methyl-p-tyrosine is an orally active inhibitor of catecholamine synthesis which inhibits the hydroxylation of tyrosine to DOPA .

HY-W015007

Metyrosine	COX	Cardiovascular Disease
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .

HY-W002291

p-Fluoro-L-phenylalanine 4-Fluoro-L-phenylalanine	Biochemical Assay Reagents	Others
p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli (K_D=0.26 μM) .

HY-105058A

14α/β-Vindeburnol 14α/β-RU 24722	Others	Neurological Disease
14α/β-Vindeburnol (14α/β-RU 24722) a synthetic molecule derived from the eburnamine-vincamine alkaloid group, has many neuropsychopharmacological and antidepressant-like effects .

HY-125693

L685818	Fungal	Infection Neurological Disease
L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans .

HY-N3548

Catalpalactone	NF-κB	Inflammation/Immunology
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-W015007S

Metyrosine-13C9,15N,d7	COX	Cardiovascular Disease
Metyrosine- ¹³C₉, ¹⁵N,d₇ is the deuterium, ¹³C-, and 15-labeled Metyrosine. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

HY-W008452S

H-Tyr(3-I)-OH-13C6	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH- ¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite[1][2].

HY-N7512

Asimilobine	Dopamine Receptor 5-HT Receptor Parasite	Infection Cancer
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity .

HY-B1904A

Fluphenazine decanoate dihydrochloride	Dopamine Receptor	Neurological Disease
Fluphenazine decanoate dihydrochloride is a dopamine D₂ receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .

Cat. No.	Product Name	Type

HY-W002291

p-Fluoro-L-phenylalanine 4-Fluoro-L-phenylalanine	Biochemical Assay Reagents
p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli (K_D=0.26 μM) .

Cat. No.	Product Name	Target	Research Area

HY-W013407

α-Methyltyrosine methyl ester hydrochloride	Peptides	Neurological Disease
α-Methyltyrosine methyl ester hydrochloride is a competitive **tyrosine hydroxylase** inhibitor that inhibits the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W008452

H-Tyr(3-I)-OH	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-Tyr(3-I)-OH is a potent and effective **tyrosine hydroxylase** inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-N3550

Catalponol	Other Terpenoids Catalpa ovata G. Don Classification of Application Fields Terpenoids Source classification Plants Bignoniaceae Disease Research Fields Cancer	Others
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-N3548

Catalpalactone	Structural Classification Natural Products Catalpa ovata G. Don Source classification Plants Bignoniaceae	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-N7512

Asimilobine	Infection Alkaloids Monophenols Classification of Application Fields Source classification Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Disease Research Fields Nymphaeaceae	Dopamine Receptor 5-HT Receptor Parasite
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73564

	Tyrosine Hydroxylase Protein, Human (sf9, His) DYT14; TH; TYH dystonia 14; TYH; tyrosine 3-monooxygenase	Human	Sf9 insect cells
	Tyrosine hydroxylase is a key enzyme in the biosynthesis of catecholamines, catalyzing the conversion of L-tyrosine into L-dopa, which is the rate-limiting step in the synthesis of dopamine, norepinephrine, and epinephrine. Tyrosine is hydroxylated using tetrahydrobiopterin and oxygen. Tyrosine Hydroxylase Protein, Human (sf9, His) is the recombinant human-derived Tyrosine Hydroxylase protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Tyrosine Hydroxylase Protein, Human (sf9, His) is 496 a.a., with molecular weight of ~57.6 kDa.

HY-P73563

	Tyrosine Hydroxylase Protein, Mouse (sf9, His) DYT14; TH; TYH dystonia 14; TYH; tyrosine 3-monooxygenase	Mouse	Sf9 insect cells
	The Tyrosine Hydroxylase protein serves as a crucial catalyst in the biosynthesis of catecholamines, including dopamine, noradrenaline, and adrenaline, overseeing the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa)—a pivotal and rate-limiting step in this biochemical pathway. Through the utilization of tetrahydrobiopterin and molecular oxygen, Tyrosine Hydroxylase efficiently transforms tyrosine into L-Dopa, showcasing its central role in the production of essential neurotransmitters. Beyond its primary function, the enzyme exhibits versatility by also catalyzing the hydroxylation of phenylalanine and tryptophan, albeit with lower specificity. Intriguingly, Tyrosine Hydroxylase extends its influence to developmental processes, positively regulating the regression of retinal hyaloid vessels during postnatal development, highlighting its multifaceted engagement in both neurotransmitter synthesis and physiological development. Tyrosine Hydroxylase Protein, Mouse (sf9, His) is the recombinant mouse-derived Tyrosine Hydroxylase protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Tyrosine Hydroxylase Protein, Mouse (sf9, His) is 497 a.a., with molecular weight of ~65 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-W015007S

Metyrosine-13C9,15N,d7
Metyrosine- ¹³C₉, ¹⁵N,d₇ is the deuterium, ¹³C-, and 15-labeled Metyrosine. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

HY-W008452S

H-Tyr(3-I)-OH-13C6
H-Tyr(3-I)-OH- ¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P80362

Tyrosine Hydroxylase Antibody	WB, ICC, IHC-P, FC, IF	Human, Mouse, Rat
Tyrosine Hydroxylase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 59 kDa, targeting to Tyrosine Hydroxylase. It can be used for WB,ICC,IHC-P,FC,IF assays with tag free, in the background of Human, Mouse, Rat.

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tyrosine hydroxylase

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